Thursday, July 30, 2009

Mouthwash vs. Osteoporosis

I don't know if this is true, but it is very suspicious.

I found that my molar tooth might have a cavity. We thought that it will help me to prevent teeth cavity if I use mouthwash twice per day after lunch and before sleep, so we went to buy one bottle of LISTERINE® TOTAL CARE Anticavity Mouthwash last Thursday night.

I used it in Thursday night and Friday noon, then I had a terrible pain in the left side of my left knee in Friday night. It is a one-spot type of pain. I forgot to use it in Friday night and the weekend, then the pain was gone on Sunday.

I used it again in this Monday night and Tuesday noon, then I got another terrible pain on several spots in the left side of my left knee in Tuesday night. It is so painful that I almost couldn't stand up and walk well with my left leg.

We are wondering if this pain is a osteoporosis due by mouthwash I used, so I did not use the mouthwash yesterday and my pain has been relieved very much now. The reason that we are suspicious my pain is caused by this mouthwash is because it contains fluoride and fluoride will increase the chance of osteoporosis.

What should I do now? I want to prevent teeth cavity, but I don't want osteoporosis. I still don't want the pain even it is not due to osteoporosis.

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On the label of LISTERINE® TOTAL CARE

Take advantage of 6 benefits in one mouthwash: Helps Prevent Cavities, Restores Minerals to Enamel, Strengthens Teeth, Kills Bad Breath Germs, Freshens Breath, and Fights Unsightly Plaque Above the Gum Line.

Active ingredient: Sodium fluoride 0.0221% (0.01% w/v fluoride ion) (Purpose: Anticavity)

Use: aids in the prevention of dental cavities

Warnings: Keep out of reach of children. If more than used for rinsing is accidentally swallowed, get medical help or contact a Poison Control Center right away.

Directions
• Adults and children 12 years of age and older: use twice daily after brushing your teeth with a toothpaste, vigorously swish 10 mL (2 teaspoonfuls) of rinse
between your teeth for 1 minute and then spit out, do not swallow the rinse, do not eat or drink for 30 minutes after rinsing, supervise children as necessary until capable of using without supervision
• Children under 12 years of age: consult a dentist or doctor.

Other information: store at controlled room temperature 20° - 25°C (68° - 77°F), cold weather may temporarily cloud this product

Inactive ingredients: water, sorbitol solution, alcohol (21.6%), flavors, poloxamer 407, sodium lauryl sulfate, phosphoric acid, sucralose, dibasic sodium phosphate, D&C red No. 33, FD&C blue No. 1

Questions? Call 1-888-222-0182

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Friday, July 24, 2009

July 2009 papers

Gee! It is almost end of July and I did not even put anything in yet. I am so tired this month. Anyway I will start to put some interest papers in.

Lack of direct evidence for the carbon-starvation hypothesis to explain drought-induced mortality in trees, Anna Sala, PNAS 106(26):E68.

Reply to Sala: Temperature sensitivity in drought-induced tree mortality hastens the need to further resolve a physiological model of death, Henry D. Adams, Maite Guardiola-Claramonte, Greg A. Barron-Gafford, Juan Camilo Villegas, David D. Breshears, Chris B. Zou, Peter A. Troch, and Travis E. Huxman, PNAS 106(26):E69.

Biogeochemistry: Climatic plant power, Yves Goddéris and Yannick Donnadieu, Nature 460:40-41.
Levels of atmospheric carbon dioxide constrain vegetation types and thus also non-biological uptake during rock weathering. That's the reasoning used to explain why CO2 levels did not fall below a certain point in the Miocene.

How Sweet It Is: Identification of Vacuolar Sucrose Transporters, Aleel K. Grennan and Jeremy Gragg, Plant Physiol. 2009;150 1109-1110.

A Versatile Zero Background T-Vector System for Gene Cloning and Functional
Genomics
, Songbiao Chen, Pattavipha Songkumarn, Jianli Liu, and Guo-Liang Wang
Plant Physiol. 2009;150 1111-1121.

A Visual Reporter System for Virus-Induced Gene Silencing in Tomato Fruit Based on Anthocyanin Accumulation, Diego Orzaez, Aurora Medina, Sara Torre, Josefina Patricia, Fernandez-Moreno, Jose Luis Rambla, Asun Fernandez-del-Carmen, Eugenio Butelli, Cathie Martin, and Antonio Granell, Plant Physiol. 2009;150 1122-1134.

The Role of Annexin 1 in Drought Stress in Arabidopsis, Dorota Konopka-Postupolska, Greg Clark, Grazyna Goch, Janusz Debski, Krzysztof Floras, Araceli Cantero, Bartlomiej Fijolek, Stanley Roux, and Jacek Hennig, Plant Physiol. 2009;150 1394-1410.

Two Alternatively Spliced Isoforms of the Arabidopsis SR45 Protein Have Distinct Roles during Normal Plant Development, Xiao-Ning Zhang and Stephen M. Mount
Plant Physiol. 2009;150 1450-1458.

FRIGIDA Delays Flowering in Arabidopsis via a Cotranscriptional Mechanism Involving Direct Interaction with the Nuclear Cap-Binding Complex, Nuno Geraldo, Isabel Baurle, Shin-ichiro Kidou, Xiangyang Hu, and Caroline Dean, Plant Physiol. 2009;150 1611-1618.

Green Life Through Time, Jonathan P. Wilson, Science 325(5936):36 - 37.
An expansion and update of Taylor and Taylor's classic 1993 book, this lavishly illustrated volume offers a comprehensive survey of fossil plants and fungi.

Sweet Silencing, Jeffrey A. Simon, Science 325(5936):45 - 46.
A sugar molecule plays an unexpected role in controlling gene silencing by modifying repressor proteins.

When Earth greened over, Eric Hand, Nature 460:161.
Explosion of animal life could have been triggered by blanket of vegetation.

Adaptive prediction of environmental changes by microorganisms, Amir Mitchell et al., Nature 460:220-224.
Habitats where environmental change occurs in a reliable order offer microorganisms the opportunity to prepare in advance. Here, in both the bacterium Escherichia coli and the yeast Saccharomyces cerevisiae, stimuli that typically appear early in the ecology of the organism are shown to induce genes that are useful for coping with conditions that normally occur later, a process that is also shown to improve fitness.

Plain English: Free service helps scientists get published, Nature 460:295.
Two young researchers have launched a free manuscript-editing service to help scientists from developing countries get papers published in English-language journals. Justin Chakma, a research analyst at the McLaughlin-Rotman Centre for Global Health in Toronto, Canada, and Alexander Patananan, a biochemistry doctoral student at the University of California, Los Angeles, set up SciEdit earlier this year as a spin-off of the Journal of Young Investigators, an international student-run, peer-reviewed journal. In choosing which papers to improve, it assesses the merit of the science, not just the use of English. To date, SciEdit has accepted 10 manuscripts from India, South Africa, Pakistan, China and Nepal.

Glycinebetaine-induced water-stress tolerance in codA-expressing transgenic indica rice is associated with up-regulation of several stress responsive genes, Hitesh Kathuria, Jitender Giri, Karaba N. Nataraja, Norio Murata, Makarla Udayakumar, Akhilesh K. Tyagi, Plant Biotechnology 7(6):512 - 526.

The fungal RNA-binding protein Rrm4 mediates long-distance transport of ubi1 and rho3 mRNAs, Julian König, Sebastian Baumann, Janine Koepke, Thomas Pohlmann, Kathi Zarnack and Michael Feldbrügge, EMBO 28:1855 - 1866.

DOE's Push to Train a New Generation Falters in House, Science 325(5937):130 - 131.
Secretary of Energy Steven Chu has proposed a 10-year, $1.7 billion education program called RE-ENERGYSE to help the United States find the talent to fuel its clean-energy economy. But Congress may prefer to wait until next year.

Tofu Was Just a Start, Michael A. Grusak, Science 325(5937):150.
The contributors explore the range of foods made from soybean and the other ways soy products enter our meals, highlighting how important these foods are and how important they may become.

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?, J. W.-H. Li and J. C. Vederas, Science 325(5937):161 - 165.

Ozone suppresses soil drying- and abscisic acid (ABA)-induced stomatal closure via an ethylene-dependent mechanism, SALLY WILKINSON, WILLIAM J. DAVIES, Plant, Cell & Environment 32(8):949 - 959.

Report claims no yield advantage for Bt crops, Cormac Sheridan, Nature Biotechnology 27:588 - 589 (2009).
A controversial report claims that traits introduced to food crops by genetic engineering (GE) have had, at best, a minor impact on yield.

NCBI Peptidome: a new public repository for mass spectrometry peptide identifications, Douglas J Slotta, Tanya Barrett and Ron Edgar, Nature Biotechnology 27:600 - 601.

Biomarker validation by targeted mass spectrometry, Martin McIntosh and Matthew Fitzgibbon, Nature Biotechnology 27:622 - 623.
A multilaboratory study demonstrates the potential for establishing quantitative targeted proteomic assays for moderately to highly abundant plasma proteins.

Fifteen years of microbial genomics: meeting the challenges and fulfilling the dream, Nikos C Kyrpides, Nature Biotechnology 27:627 - 632.
Now that ~1,000 microbial genomes have been sequenced, Nikos Kyrpides reflects on the past decade of microbial genomics and extrapolates forward to propose solutions to meeting challenges in the field.

Climate change: Beyond the CO2 connection, Rainer Zahn, Nature 460:335-336 (16 July 2009).
At times in the past, mobile ocean fronts in the subtropics have exercised an influence on the magnitude of climate change by decoupling temperature from levels of carbon dioxide in the atmosphere.

Global patterns of speciation and diversity, M. A. M. de Aguiar et al., Nature 460, 384-387 (16 July 2009).
The question of why biological diversity is spread in characteristic patterns is perhaps the biggest problem in ecology. In recent years, the 'neutral theory' of biodiversity has modelled the distribution of species in a very simple way, without reference to species interactions or history. Sexual reproduction, mutation and dispersal are now introduced to the simulation of populations; the resulting predictions correlate well with real data sets.

Beyond the Type Genome: Discovery of Novel Avirulence Genes in the Rice: Blast Fungus by Genomic Resequencing and Genetic Association Studies, Jennifer Mach, Plant Cell 21:1325.

Membrane Rafts and Virus Movement in Plant Cells, Nancy A. Eckardt, Plant Cell 21:1326.

PUCHI and Floral Meristem Identity, Gregory Bertoni, Plant Cell 21:1327.

A Role for Arabidopsis PUCHI in Floral Meristem Identity and Bract Suppression, Md. Rezaul Karim, Atsuko Hirota, Dorota Kwiatkowska, Masao Tasaka, and Mitsuhiro Aida, Plant Cell 21:1360-1372.
Acquisition of flower identity in Arabidopsis is associated with the
switch from an indeterminate to a determinate growth pattern and
suppression of a subtending leaf called a bract. It is shown that the
AP2/EREBP gene PUCHI, together with the NPR1-like signaling genes
BOP1 and BOP2, are required for these processes, possibly
through position-specific activation of the floral regulators LFY
and AP1.

Association Genetics Reveals Three Novel Avirulence Genes from the Rice Blast Fungal Pathogen Magnaporthe oryzae, Kentaro Yoshida, Hiromasa Saitoh, et al., Plant Cell 21:1573-1591.
This work uses genome resequencing, large-scale association genetics, and
in vivo functional complementation to identify avirulence proteins
AVR-Pia, AVR-Pii, and AVR-Pik/km/kp from among a large
set of candidate secreted proteins from the major rice pathogen
Magnaporthe oryzae.

Beneficial Biofuels—The Food, Energy, and Environment Trilemma, D. Tilman et al., Science 325(5938):270 - 271.
Exploiting multiple feedstocks, under new policies and accounting rules, to balance biofuel production, food security, and greenhouse-gas reduction.

Neutralizing Toxic RNA, Thomas A. Cooper, Science 325(5938):272.
Oligonucleotides that target aggregates of RNA and protein show potential for treating myotonic dystrophy.

What Drives Climate Flip-Flops? A. Timmermann and L. Menviel, Science 325(5938):273.
A numerical modeling study questions the validity of a key paradigm in rapid climate change studies.

The carbon count, Nature 460:436 (23 July 2009).
Scientists need better Earth-monitoring tools to see whether climate policies are working.

ExxonMobil invests in algae for biofuel, Nature 460:449 (2009).
Oil and gas company ExxonMobil, whose chief executive Rex Tillerson called the idea of ethanol as a biofuel "moonshine" in 2007, last week announced a US$600-million research alliance to develop biofuels from photosynthetic algae.

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Thursday, July 23, 2009

Land-based whale watching

It is whale watching season in east Australia. We are thinking to go to the North Stradbroke Island. But it is so expensive to transport our car to there by ferry, i.e. $135 per car and $11 per person round-trip. Then we are thinking maybe we should take those whale watching tour by boat or do land-based whale watching. It is also expensive to take the boat tour, i.e. $89-115 per person. Sigh! Maybe a land-based one?

We did go to Burleigh Head National Park and Point Danger (Coolangatta/Tweed Heads border) on July 25, 2009. It was quite windy in both places which made me headache. We saw many human-shaped seals surfing on beaches around both places. We did not see any whale but we saw dolphins swimming toward coast reef or feeding around it. It is very clean and neat places.

There is a Point Danger Lighthouse, a memorial landmark for captain Cook, in Point Danger. Hmmm, captain Cook have named so many places in Australia. There is also a sand-pumping structure in Point Danger to avoid coast erosion.


Some informations about Land based whale watching in Australia
Point Danger: Point Danger (Coolangatta/Tweed Heads border) is a pretty good spot to see the whales from land.

Byron Bay: Another good spot for land based whale watching is Byron Bay.
Byron Bay lighthouse is the most easterly point in Australia. If you walk up to the lighthouse there are posters and museum with information about the whales.

The last time I went, they were recording the whale songs and there was a local university research student who was telling us all about what was going on and what we could hear.

It was actually live whalesong being recorded from the whales that were passing. Fascinating stuff.

That day, there was a lot of whale activity and we stayed at Byron Bay just enjoying the atmosphere for hours.

South Stradbroke Island: Although you are not high up on South Stradbroke Island you can be lucky with whales coming in close to shore. The beach is pristine there, so even if you don't see whales you can enjoy the solitude of the beach. You can usually join a whale watching tour from Couran Cove Resort.

North Stradbroke Island: I haven't been there yet but I understand that there can be some good whale watching from the northern tip of North Stradbroke Island. You can self drive to Cleveland and take a ferry across to Dunwich and then drive about 32 kms to the point. North Stradbroke Island has an aptly named resort right at the point: Whale Watch Ocean Beach Resort!

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Saturday, July 18, 2009

Metagenomics

I found this "metagenomics" is quite attractive. I am thinking to study this field for what it can do to understand our environment and solve environmental problem. I feel bad that I didn't know this field until July 7, 2009.

Metagenomics and Our Microbial Planet by National Academics

Metagenomics (also Environmental Genomics, Ecogenomics or Community Genomics) is the study of genetic material recovered directly from environmental samples. Traditional microbiology and microbial genome sequencing rely upon cultivated clonal cultures. This relatively new field of genetic research enables studies of organisms that are not easily cultured in a laboratory as well as studies of organisms in their natural environment.

Search result by google Scholar
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