Transient transcriptional responses to stress are generated by opposing effects of mRNA production and degradation, Ophir Shalem, Orna Dahan, Michal Levo, Maria Rodriguez Martinez, Itay Furman, Eran Segal & Yitzhak Pilpel. Molecular Systems Biology 4: 4 (14 October 2008).
The death of microarrays? Heidi Ledford, 15 October 2008 | Nature 455, 847 (2008).
High-throughput gene sequencing seems to be stealing a march on microarrays. Heidi Ledford looks at a genome technology facing intense competition.
Snapshot: Green ham (no eggs), 15 October 2008 | Nature 455, 848 (2008), This year's chemistry Nobel.
Editor's Summary: Cell cycle: what a difference a splice makes, Nature 455 (16 October 2008).
Genome-wide analyses in yeast have shown that the switch from mitosis to gamete-forming meiosis is associated with a dramatic change in gene expression profiles.
Molecular biology: Bound to splice, Bruce Futcher and Janet K. Leatherwood, Nature 455, 885-886 (16 October 2008).
Messenger RNAs don't usually correspond exactly to DNA — portions of the primary transcript, known as introns, are removed by splicing. A study reveals new ways in which splicing can be regulated.
Promoter-driven splicing regulation in fission yeast, Alberto Moldón, Jordi Malapeira, Natalia Gabrielli, Madelaine Gogol, Blanca Gómez-Escoda, Tsvetomira Ivanova, Chris Seidel & José Ayté, Nature 455, 997-1000 (16 October 2008).
GENETICS: It's the Sequence, Stupid! , H. A. Coller and L. Kruglyak, Science 322 (5900):380 - 381 (17 October 2008).
Differences in regulatory DNA sequences drive species-specific gene expression.
Wednesday, October 15, 2008
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